Don and Mimi Galvin's dream of raising a picture-perfect family in Colorado Springs gets thwarted as their eldest son, Donald, begins to act strangely.

As Donald is released from the hospital, the family's home life is thrown into turmoil, forcing some to leave. Brian's rockstar dreams end in tragedy.

After one family member dies, 14-year-old Peter has a psychotic breakdown and a family secret forces Mary into an unthinkable situation.

Mimi dies, causing a rift in the family -- the next generation fears they'll develop schizophrenia. Scientists use the Galvins' DNA to find a cure.